Pharmaceutical Industry

Particle size directly affects product properties, and is therefore a critical parameter in the manufacture of pharmaceutical products. Likewise, pellet size is significant for the safety and potency of its bioactive agents and for offering flexibility in dosage forms. Precision of particle and pellet size in pharmaceuticals is key to product efficacy, necessitating strict quality control. ImageProVision Technology Pvt. Ltd. plays a pivotal role in this regard, through products that accurately determine size.

Our Products

Particle Size Analyser

Particle size can influence the processability of powders, both API and excipient, and affect the final formulation. In order to maintain uniformity and obtain maximum efficacy from product, particle size distributions need to be studied, with quality control at key stages in production. The PSA is a powerful tool for research and development and quality control, determining size promptly, accurately and conveniently.

Explore the Particle Size Analyser - Technical Note Brochure

Technical Overview

The PSA is a compact and reliable microscopic software analysis system that includes both the digital microscope as well as the software. Digital microscopy enables high resolution imaging, while the software conducts accurate and sensitive identification of particulate solids and agglomerations in solutions, from those images. The results are computed, tabulated and observed in real time.

Features:

  • Analysis and characterization of particles, 0.7 microns to 2000 microns in size

  • Software identifies morphology and classifies particles as isolated particles, agglomerations etc.

  • Statistics generated:

    • Particle size
    • Classification based on particle size
    • Average particle size
    • Size distribution shown graphically
    • Coefficient of variation
    • Classification based on particle shape
    • Reports displayed in an Excel sheet with images, in PDF or print format

Benefits:

  • Maintenance of a more consistent product, improving end-user value and eventually, profitability
  • May be used at any stage, reducing modifications and process repetition, resulting in efficient, streamlined processes and superior products
  • Automatic analysis through software, requiring no manual effort
  • Real-time analysis
  • High accuracy, measuring up to microns
  • Easy to use, offering multiple configuration possibilities to enable the user to adapt the system to his requirements
The Intelligent Particle Size Analyser & Classifier (PClass)

Particle size is key to the formulation of pharmaceutical products, affecting processability, appearance, performance and stability of the final product. Shape, texture and microstructure are equally important parameters used in research as well as quality control for a stable, effective product. The PClass is an advanced version of the Particle Size Analyser, rendering these analyses with speed, convenience and accuracy.

Analysis Methodology

The PClass analyses samples using two methods -

Particle Size Distribution

This method analyses and records the overall particle size distribution. The software computes factors such as D0.1, D0.5, D0.9, maximum, minimum and average size, etc. The report generated may be customized to include the image, histogram and relevant statistical data. The user may also compare data from various samples by super-imposing graphs.

API Identification

The software algorithm intelligently analyses and obtains relevant information from video analysis, image statistics and shape analysis. The algorithm can identify and classify the various APIs from within mixtures of creams, oils, gels or globules. Customized analysis reports may be derived for only selective and relevant data, using colour-coded graphic representations as required, such as line graphs, bar graphs etc. Graphs from multiple samples may also be superimposed for a quick, easy comparison.

Explore PClass Technical Note Brochure

Technical Overview

At ImageProVision, we believe in innovation and continuous improvement. We base our solutions on this philosophy and on what we learn from listening to clients about their requirements. This has directed our efforts towards delivering customized solutions that target these demands and meet specific industry needs.

The PClass is a compact and reliable microscopic software analysis system that includes both the digital microscope as well as the software. Apart from identification of particulate solids and agglomerations in solutions and analysing size distributions, the PClass also analyses shapes, textures and microstructures. The software intelligently monitors the procedure, identifies errors and enables the user to take corrective action to complete the procedure accurately.

Features:

  • FDA 21 CFR Part 11 compliant
  • Software offers multi-level authentication, electronic signatures, digital data security, audit trail etc.
  • Identification and measurement of APSs and agglomerations
  • Identification and measurement of particles in multiple layers, on the same run
  • Selective measurement of particles based on size, shape and type
  • Selective measurement of particles based on size, shape and type
  • Selective scan of sample areas, simultaneously or post run
  • Intelligent checks and easy-to-follow guidelines throughout the process

Benefits

  • Simple, user-friendly, flexible and interactive software
  • Elegant PC interface, allowing direct control of digital camera mounted on the microscope for collection and analysis of images
  • The procedure is monitored, errors identified and corrective actions are recommended for accurate and smooth operation
  • Immediate analysis and report generation
  • Customized reports using relevant information

Pellet Size Analyser

In the pharmaceutical industry, regularity in the size of granules or pellets is a vital parameter for filling capsules and is key to quality. Quality control at any stage of production may be carried out quite simply and accurately using the Pellet Size Analyser, easily overcoming the problem with time and accuracy that occurs when this task is performed manually.

Explore the Particle Size Analyser - Technical Note Brochure

Technical Overview

The Pellet Size Analyser is a software-based system including an HD camera unit and software. The pellets are placed within the inspection unit, and the image, recorded by the image-capturing software. The analysis software accurately measures the size of all particles and computes the particle size distribution. The results are charted in Excel and print format. The software performs this function in just a matter of seconds.


Features:

  • Automatic analysis - Being a computer-based system, analysis is carried out automatically by the software, requiring no manual intervention

  • Real-time analysis on a computer screen

  • High accuracy - The Pellet Size Analyser has an accuracy of over 99% in microns

  • Statistics - The various statistics measured by the Pellet Size Analyser include:

    • Pellet size
    • Classification based on pellet size (500-1000 microns, 1000-2000 microns etc.)
    • Average pellet size
    • Size distribution shown graphically
    • Coefficient of variation
    • Classification based on pellet size
  • Reports - Resultant statistics are provided in an Excel sheet with images, in PDF format or print format

  • User-friendly - The Pellet Size Analyser is easy to use, offering multiple configuration possibilities to enable the user to adapt the system to his requirements