Microscopy-based Particle Size Analysis vs. Other Techniques

R& D department of Pharmacy Companies and scientists working with Research and Development will be guided by the following facts about the microscopy-based particle size analysis versus other related techniques and insights regarding particle characterization, particle classification and particle size distribution.

The behavior of particulate substances is usually dominated by constituent particles’ physical properties. These can also affect other material properties such as dissolution and reaction rates, abrasivity and compressibility, and how easily ingredients mix and flow. From development to manufacturing perspective, there are several essential physical properties to measure and these include the following:

  • Particle shape
  • Particle size
  • Mechanical properties
  • Surface properties
  • Charge properties
  • Microstructure

Particle shape and particle size are the two most important and easy to measure properties.

What is Particle Size?

A particle is a discrete sub portion of a substance such as solid particles, gas bubbles and liquid droplets with physical dimension like sub-nanometer and millimeters in size. The following are common types of some materials containing particles:

  • Emulsions, suspensions, and slurries such as milk, vaccines and mining muds
  • Sprays and aerosols like crop protection spray and asthma inhalers
  • Granules and powders such as cement, pigments and pharmaceutical ingredients

Laser diffraction is a particle-sizing technique used for materials with nanometers and millimeters in size. Dynamic light scattering is a non-invasive technique used to measure particle size and macromolecules. Automated imaging refers to high resolution direct technique used for particle characterization. Electrophoretic Light Scattering is used in measuring particle electrophoretic mobility in dispersion or solution.

The criteria you must consider in deciding which particle characterization technique you need:

  • What particle size range do you want to work with?
  • Which particle properties are essential to you?
  • Are your samples polydiverse or do you need a wide dynamic range?
  • How fast do you need to make measurements?
  • Do you need to measure at high resolutions?
  • Do you need good statistical sampling for strong QC measurement?
  • How much cash are you prepared to spend?
  • Do you need to disperse your sample dry or wet?

Various Technologies Available to Analyze Particle

In the latest instruments, Non-Invasive Back-Scatter technology expands the sizes and concentrations of the samples that need to be measured. The sizing ability of these instruments can detect light scattering such as in the backscatter detection.

Why Shape is Important?

Particles are intricate three-dimensional substances with particle size measurement with simplified particle description needed to measure and make data analysis. Particle shape is measured by imaging techniques in which data are gathered with two-dimensional projection. Parameters for particle shape are calculated through two-dimensional projection with simple geometrical calculations.

Life cycle controlling increases interest and the significance to the pharmaceutical companies. Drug-delivery technologies that provide positive variation over first-generation marketable products deliver an essential means for remaining competitive in today’s perplexing business environment. Top drug-delivery technologies using an exclusive milling process that has manufactured nanotechnology-enabled products are NanoCrsytal technology from elan Drug Technologies, Insoluble Drug Delivery technology from SkyePharma, Biorise technology and a lot more.

Understanding the basic concepts in the microscopy-based particle size analysis over other techniques and technologies is essentially needed for scientists and pharmacy companies in order for them to succeed in their development and manufacturing endeavors.

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